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Lakhan, S

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Key findings include: Upregulation of Shh pathway components in ischemic brain regions Enhanced neural stem cell proliferation and differentiation Improved angiogenesis supporting tissue repair Modulation of blood-brain barrier integrity The Shh pathway activation appears particularly relevant in stroke recovery models, where enhanced neurogenesis and vascular support correlate with functional improvements

This section consolidates the major molecular mechanisms through which luteolin exerts therapeutic effects, highlighting cross-talk among pathways to illustrate its systems-level regulatory profile