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However, as discussed below, the single screening round of DMSA had an unexpectedly dramatic effect on improving abnormal glutathione and platelet levels, and that effect lasted until the end of phase 2, so that phase 2 was not a placebo-controlled investigation

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These can significantly alter the biological activity and lead to unreliable experimental outcomes

K., Gandhi, A

That action can cause nausea, vomiting, or decreased food and fluid intake, which may indirectly produce headaches through dehydration or low blood sugar