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Pulmonary vascular remodeling, a hallmark of PAH, is primarily driven by the excessive proliferation and reduced cell death of pulmonary artery smooth muscle cells (PASMCs) [140, 141]

Avoid eating or drinking anything after midnight, including water, to prevent nausea during the procedure

For example, recent findings indicate that HSPA1B facilitates the exosomal secretion of metalloproteinases from macrophages, thereby helping to mitigate fibrosis (Xiao et al., 2025)

FIGURE 8 Statements Data availability statement TThe data presented in the study are deposited in the NCBI-SRA ( repository, accession number PRJNA1278808

Safe profile: Clinical trials show AOD-9604 is well tolerated with a side-effect rate similar to placebo