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Myth: Freezing semaglutide will make it last longer

The larger volume also means a slower injection if you are using a smaller gauge needle, which some people find more comfortable

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The MedlinePlus semaglutide injection guide lists headache as a possible adverse effect and advises contacting a clinician if it is severe or does not go away

This is the most clinically significant concern, as sustained heart rate elevation can increase cardiovascular risk in predisposed individuals Elevated blood pressure modest increases in both systolic and diastolic blood pressure were noted Restlessness and anxiety related to increased norepinephrine and dopamine activity Constipation reported by approximately 1520% of participants Nausea less common than with GLP-1 medications, reported by approximately 10% The cardiovascular effects elevated heart rate and blood pressure are the primary safety concerns with tesofensine