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In contrast, LepR is expressed in sub-populations of neurons located in the lateral hypothalamus (136138) a region known to directly and indirectly influence the histaminergic neurons (139, 140)

Metabolic dysfunction is among the most important of those antecedents, and visceral adiposity is among the most tractable intervention targets

Further investigation is required to determine whether this polygenic score influence pharmacotherapy outcomes (57)

Chronic lung disease in heart failure with preserved ejection fraction In a nationwide cohort study, it was demonstrated that GLP-1 RAs were associated with a reduced risk of cardiopulmonary complications and all-cause mortality compared to non-GLP-1 RAs in patients with T2D and COPD

Several small clinical studies and case reports have documented significant reductions in hyperphagia and weight loss in PWS patients treated with GLP-1 agonists, though large-scale randomized trials are still limited