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These include: Nausea (reported in a significant proportion of participants, particularly during dose escalation) Vomiting and diarrhoea Constipation and abdominal discomfort Decreased appetite , which, whilst contributing to weight loss, can occasionally lead to inadequate nutritional intake Most gastrointestinal effects were described as mild to moderate in severity and tended to diminish over time

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This overview is based on previously conducted studies and does not contain new data/results of human participants or animals performed by the authors

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