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Sporadic variants associated with CNSHA are not likely to spread

[2] If cramps coincide with dose increases, inform your prescriberthey may advise maintaining the current dose longer before escalating, as indicated in the SmPC

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CCO is the terminal enzyme in the mitochondrial electron transport chain (ETC) ( During PBM for KOA, this molecular cascade activates CCO in synovial macrophages, releasing NO that collectively restarts mitochondrial respiration and initiates downstream signalling networks ( Figures 1 , 2 )