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Orthogonal validation of NMR fragment hit 27 Encouraged by the relatively high binding affinity of compound 27 compared to expectations for fragments, we synthesised a series of analogues to explore the effect of modifying both the sulfonic acid and the ethoxy substituents on binding affinity (Table 1)

Cregger, M

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During a pregnancy without complication and after a straightforward birth, there is generally low risk of significant blood mixing between the mother and the baby