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[CrossRef] [Google Scholar] Direct Characterization of Bulk Samples by Internal Extractive Electrospray Ionization Mass Spectrometry

Importantly, tBHP-induced cell death and HMGB1 release were largely inhibited by classic ferroptosis inhibitors such as ferrostatin-1 (Fer-1) and deferoxamine (DFO), indicating the induction of ferroptosis (Fig

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Activation of SLC7A11 expression enables cells to restore redox homeostasis and maintain survival under stressful conditions such as oxidative stress, amino acid starvation, metabolic stress, and genotoxic stress ( c is driven by concentrations gradient from extracellular Cys and intracellular Glu, transporting Cys and Glu in a 1:1 ratio (Figure 1)