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GCL is considered the speed limiting enzyme of synthesis since overexpression of GS does not increase GSH levels while overexpression of GCL increases the synthesis of GSH (61) (Figure 3)

Currently, there is only two classes of drugs approved for the treatment of AD: N-methyl D -aspartate (NMDA) antagonist (memantine), and cholinesterase inhibitors (tacrine, Donepezil, galantamine, rivastigmine)

[DOI] [PubMed] [Google Scholar] 149.Peng J, Awad A, Sar S, et al

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