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Silencing the expression of NCOA4 by RNAi knockdown significantly inhibited ferritinophagy, thereby suppressing ferroptosis in mouse embryonic fibroblasts ( In addition, excess intracellular Fe 2+ can also be exported through ferroportin (FPN) on the cell membranes, which is the only known vertebrate iron efflux pump ( 2+ can be changed, and ferroptosis can be mediated

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TB-500 is a synthetic 17-amino-acid fragment of Thymosin Beta-4 (TB4) , a 43-amino-acid actin-binding protein (molecular weight ~4,963 Da) present in nearly all human cells except red blood cells