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Targeted protein degradation: a promise for undruggable proteins

doi: 10.1016/j.molcel.2017.05.032 17 BrightNJThorntonCCarlingD

17 Up to 30% of GLP-1 drugs are acquired by patients through compounding pharmacies rather than large manufacturers like Novo Nordisk or Eli Lilly

Significantly elevated mucosal TPH1 expression in obese humans (38, 39) and elevated levels of circulating 5-HT in individuals with type 2 diabetes (T2D) (4042) or obesity (38) has been reported