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EMA, 2024)

Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial

Patients who utilized oral semaglutide in combination with metformin and an SGLT-2i had the longest mean LOT length of 153.8 days

Bibcode:2020PLoSO..1532676R

Patients should be advised to: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or spicy foods that delay gastric emptying further Reduce intake of foods that commonly trigger nausea (strong odors, very sweet items) Stay well-hydrated with small sips of water throughout the day Avoid lying down immediately after eating (remain upright for 2-3 hours) Gradual dose titration is critical for improving tolerance