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There is a black box warning (the FDAs strongest alert about serious side effects) for a rare thyroid cancer called medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN-2), a genetic condition that causes these tumors

As above mentioned, due to ghrelin orexigenic action, hyperghrelinemia has been suggested as a potential cause of increased appetite and weight gain in patients with PWS [49]

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