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Essentially flipping the metabolic switch from anabolic to catabolic metabolism
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Diencephalon The arcuate nucleus (ARC) of the hypothalamus plays a particularly important role in the central regulation of food intake ( in situ hybridization (Merchenthaler et al., 1999
Evidence Quality Summary Honest appraisal of the evidence hierarchy for this stack: | Claim | Evidence Level | |---|---| | Ipamorelin raises GH via GHSR-1a | Strong: mechanistic + animal + human Phase I | | CJC-1295 raises GH and IGF-1 in humans | Moderate: Phase II RCT (N=65) | | Combination produces synergistic GH pulses | Moderate in animals
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