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PR-104 showed linear pharmacokinetics, rapid conversion to PR-104A, and evidence of antitumor activity, including partial responses and prolonged stable disease in some patients (282)

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The ATF4-mediated upregulation of amino acid transporters and one-carbon metabolism, including SLC1A1, SLC7A8 , and SHMT2 , presumably increases the supply of glutamate, cysteine, and glycine, which might act in concert for the biosynthesis of GSH

U tych pacjentw nie tylko zaobserwowano spadek masy ciaa , ale rwnie: wyregulowanie stenia glukozy we krwi, popraw insulinowraliwoci komrek, obnienie poziomu hemoglobiny glikowanej

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