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In Vivo findings have suggested that this process depends greatly on the actions of both -glutamyltransferase and cysteinylglycinase, which form conjugates of l-cysteine ( e.g
doi: 10.1016/j.cryobiol.2023.03.003 91 BriardJGPoissonJSTurnerTRCapicciottiCJAckerJPBenRN
DHAR activity also maintained the ascorbate pool in mutants that have low ascorbate accumulation (Terai et al
Rae CD, Baur JA, Borges K, Dienel G, Daz-Garca CM, Douglass SR, Drew K, Duarte JMN, Duran J, Kann O, Kristian T, Lee-Liu D, Lindquist BE, McNay EC, Robinson MB, Rothman DL, Rowlands BD, Ryan TA, Scafidi J, Scafidi S, Shuttleworth CW, Swanson RA, Uruk G, Vardjan N, Zorec R, McKenna MC (2024) Brain energy metabolism: a roadmap for future research
Conclusion Findings highlight the importance of giving participants questionnaires that contain content relevant to them, and ensuring they know these PROs can influence their treatment/management
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