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Moreover, a trend toward a lesser likelihood of recurrence was discovered among patients undergoing either GTR alone or STR with radiation therapy compared with STR alone (p = 0.061)

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Concerns about adverse effects, particularly the risk of dependence, and reports of tinnitus exacerbation upon discontinuation 115 indicate the need for caution, and future research could clarify whether specific patient subgroups might benefit from targeted, short-duration BZD therapy under strict clinical supervision

Levtchenko EN, van Dael CM, de Graaf-Hess AC, Wilmer MJ, van den Heuvel LP, Monnens LA, Blom HJ (2006) Strict cysteamine dose regimen is required to prevent nocturnal cystine accumulation in cystinosis