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One of the leading mechanisms of astrocyte-associated neurotoxicity is associated with severe decrease in the expression of glutamate transporters, the presence of which is reduced, in ALS patients, to only ~10% of the levels in healthy subjects

80 These morphologic alterations are a consequence of the oxidative assault on hemoglobin

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Until very recently, only alginate-containing formulations 129,130 given as add-on medicationsproved to be capable of improving symptom control in endoscopy-negative patients

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