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However, it is necessary to directly study muscle cells, since there are key differences in the signalling and trafficking machinery between adipocytes and myocytes, for example in the major Rab proteins responsible for insulin-regulated GLUT4 delivery to the cell surface (Rab8a and 13 in muscle [118]

Science 349:10711075 Kataya AMR, Reumann S (2010) Arabidopsis glutathione reductase 1 is dually targeted to peroxisomes and the cytosol

Semaglutide targets one pathway (GLP-1), retatrutide targets three hormone pathways (GLP-1, GIP, and glucagon)

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The GLP1RA exenatide is reported to attenuate alcohol, cocaine, amphetamine and nicotineinduced increases in accumbal or lateral septal dopamine levels in rats [51, 64, 65, 66, 67, 68]