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Plant Cell 27 , 25452559 (2015)

Obesity treatment guidelines emphasize a stepwise approach, focusing initially on evidence-based nutrition and lifestyle modifications centred on hypocaloric dietary patterns and physical activity regimens, tailored to individual needs, followed by escalation to pharmacotherapy and bariatric surgery [[4], [5], [6], [7]]

According to NICE guidance (NG28) , GLP-1 receptor agonists are recommended as add-on therapy when glycaemic targets are not met with other treatments

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