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This combination has shown greater weight loss than either therapy alone

Cardiovascular death When compared to placebo, GLP-1 RAs were associated with a non-significant reduction in cardiovascular death in CKD patients (RR 0.87, 95% CI 0.551.39

As mentioned, a secondary analysis of an RCT assessing the cardiometabolic effects of exenatide in 40 people with schizophrenia 140 also looked at measures of cognition and psychosocial functioning (that is, Brief Assessment of Cognition in Schizophrenia, ReyOsterreith Complex Figure Test, Short-Form Health Survey, Personal and Social Performance Scale, Positive and Negative Syndrome Scale), but found no effect for this GLP-1RA compared with placebo over 3 months 133

Regulatory and ethical issues apply

Cell death at this time point was indiscriminate, as the lesion site was largely devoid of neuronal (NeuN + ), astrocytic (GFAP + ), oligodendrocyte (APC + ), and microglia (Iba1 + ) staining (all in green)