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If yes, decrease the dose

Semaglutide and tirzepatide pricing exemplifies this dynamic

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Kidney stones - When a kidney stone becomes trapped in one of the ureters (the narrow tubes connecting each kidney to the bladder), it can cause severe pain in the back, side or groin, nausea and vomiting, or painful and frequent urination

And long-term safety studies in humans would address the most significant remaining uncertainty about the compound