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MT-2 is a cyclic heptapeptide with a lactam bridge to create greater potency, prolonged duration, but also stronger agonism on MC3R and MC4R receptors, which can result in side effects like libido increase, nausea, changes in appetite, In preclinical research, MT-1 5mg is chosen when a targeted MC1R profile is desired and MT-2 as broader melanocortin activation