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Kuriki J., Murakami H., Kakumu S., Sakamoto N., Yokochi T., Nakashima I., Kato N

Inflammation and gut microbiota play crucial roles in both psychological distress and liver disease initiation and progression, while the sickness behavior theory explains that peripheral inflammation can lead to behaviors like fatigue, lethargy, impaired concentration, and social withdrawal

Individuals with strong genetic loading for obesity may respond poorly to caloric restriction alone, regardless of app engagement

In contrast, Mounjaro trials often report lower initial rates, frequently cited between 12% and 18% at the starting doses

Baxter SM, et al