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The mechanism by which metformin leads to apoptosis through cell cycle arrest can be explained as follows: when cells are blocked at specific cycle stages, they are unable to complete the normal process of DNA replication and division, resulting in increased intracellular pressure and accumulation of DNA damage, and these changes ultimately trigger the cells apoptosis program (63)
Pre-operative iron deficiency is associated with higher risk of perioperative anemia and delayed recovery
AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C
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Subsequently, Nrf2 binds to antioxidant response elements (ARE), triggering the transcription and expression of downstream antioxidant genes such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)
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