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Here this double-blind, placebo-controlled trial randomized participants previously treated with tirzepatide (cohort 1: N = 205) or semaglutide (cohort 2: N = 171) during the SURMOUNT-5 study to orforglipron once daily or placebo

Cardiorenal benefits Improved endothelial NO, natriuresis, and reduced inflammation translate into fewer MACE events in outcome trials

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