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Consult your licensed healthcare provider before making any changes to your medication, diet, or exercise protocol

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The Nrf2-ARE signaling pathway activates and enhances the expression of downstream antioxidant enzymes, serving as a critical cellular defense mechanism against oxidative stress (236)

Management includes increasing dietary fibre gradually, maintaining adequate hydration, regular physical activity, and using laxatives (osmotic, bulk-forming, or stimulant) under medical guidance