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They do not address underlying metabolic dysfunction and stop working when discontinued

Tirzepatide, in its turn, also demonstrates prolonged activity with a half-life of approximately five days

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The Akt/GSK3 signaling pathway mediates the formation of stabilized dephosphorylated -Catenin, which is then translocated to the nucleus, where it regulates the transcriptional expression of its target genes (Ki et al., 2020)

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