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PPDK can catalyse a reversible three-step reaction sequence at two separate active sites that interconverts ATP, phosphate and pyruvate to phosphoenolpyruvate (PEP), pyrophosphate and AMP (Fig

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As Nano-QSAR model quantitatively describes the relationship in the form of mathematical equations, it is very dependent on the accuracy of the descriptors

However, the saturation effect beyond this level implies that supplementation should be individualized, as excess B12 is unlikely to confer additional benefits