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Lillys R&D pipeline now includes: Next-gen tirzepatide analogs : Lilly has analogues of tirzepatide (to extend patent life) and related peptides in clinical trials

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Both are administered as once-weekly subcutaneous injections and both require gradual dose titration to minimize gastrointestinal side effects and other adverse events

These SAR studies established the conformational basis for melanocortin receptor subtype selectivity and the design principle that cyclisation of the -MSH pharmacophore core produces central melanocortin receptor-preferential biology

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