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Part 2 Insurance companies: Fixed margin Want costs to rise predictably and steadily, not by surprise In support of GLP1s over time, not immediately, so they can be priced in PBMs: Benefit from higher priced drugs with rebates Pharmacies: Benefit from volume of prescriptions Benefit from foot traffic from prescriptions Pharma: Benefit from blockbuster drugs Summary of existing players: four key stakeholders benefit from higher priced blockbusters drugs over a long-term time horizon under most circumstances

Manufacturing complexity Peptide synthesis requires specialized equipment and expertise

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Clinical evidence, however, presents a complex narrative, with some studies suggesting benefits in weight maintenance and improved quality of life, while others report more equivocal outcomes