Are they based on clinical evidence, or are they purely anecdotal
Patients should be advised to seek immediate medical attention if they experience severe or persistent gastrointestinal symptoms, signs of dehydration, inability to tolerate oral intake, severe constipation with abdominal distension, right upper quadrant pain with fever or jaundice, or symptoms suggestive of pancreatitis or bowel obstruction
Establish a monitoring plan that includes regular follow-up visits, laboratory testing as indicated, and clear instructions for when to contact your healthcare team
Extension studies have followed patients for multiple years with continued efficacy and safety
Clinically significant antibody reactionsthose resulting in treatment failure, serious hypersensitivity, or medication discontinuationremain rare events