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In these cases, complementary approaches that use DAmP (decreased abundance by mRNA perturbation) alleles can be used [65]

The MTHFR gene produces an enzyme that helps create methylfolate, a critical form of folate for overall health

In the SYNERGY-NASH trial, tirzepatide showed significant rates of MASH resolution, up to 62%, compared to 10% with placebo, and improved fibrosis in over 50% of participants, said Isaacs

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