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Clinical Findings of Target Organ Damage Target Organ Damage Hypertensive encephalopathy Intracranial hemorrhage Unstable angina Acute myocardial infarction Acute left ventricular failure with pulmonary edema Dissecting aortic aneurysm Eclampsia Clinical Findings Funduscopic: papilledema, hemorrhage, exudates Neurologic: somnolence, confusion, seizures, coma, visual deficits or blindness Cardiac: S4 gallop, ischemic changes on ECG, chest x-ray consistent with pulmonary edema, chest pain Renal: oliguria, progressive azotemia, hematuria, proteinuria Other: dyspnea Reprinted with permission from JNC-VII.

The COA is published, not promised

The measurement forgiveness at this concentration is excellent since being off by a unit only changes your dose by 0.01mg

The first few weeks usually bring a shedding phase where things get visibly worse before anything improves, and a lot of people have a hard time preserving through this stage

Degnan PH, Taga ME, Goodman AL