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Timing considerations affect some users more than others

Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition

Stocchi F, Antonini A, Barone P, Tinazzi M, Zappia M, Onofrj M, Ruggieri S, Morgante L, Bonuccelli U, Lopiano L, Pramstaller P, Albanese A, Attar M, Posocco V, Colombo D, Abbruzzese G, group Ds (2014) Early DEtection of wEaring off in Parkinson disease: the DEEP study

[2] In addition to actions at receptors, Semax, as well as a related peptide drug, Selank, have been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides (IC 50 = 10 M), though the clinical significance of this property is uncertain