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Chronic administration of high doses of oral levocarnitine in patients with severely compromised renal function or in ESRD patients on dialysis may result in accumulation of the potentially toxic metabolites, trimethylamine, and trimethylamine-N-oxide, since these metabolites are normally excreted in the urine
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It was done by one of the UK medical schools
Diabetes mellitus-induced microvascular destabilization in the myocardium
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