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Therefore, considering the overlapping yet distinct roles of insulin and IGF-1 in the brain, disruptions in their signaling pathways due to IR may contribute to the neurobiological mechanisms underlying depression in individuals with T2DM

Acknowledgements This work was supported by US National Institutes of Health grants HL116264-5244 and HL121233 and Advancing a Healthier Wisconsin Endowment (to M.L.) and National Natural Science Foundation of China grants Nos

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