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The relationships of bronchiectasis and NE release to infection were supported by the observation that antibiotic treatment significantly reduces sputum NE

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For instance, miR-424-5p suppresses granulosa cell proliferation and induces senescence via the CDCA4-mediated Rb/E2F1 pathway (Yuan et al., 2021)

This complex symptomatology reflects the widespread and multisystem nature of PD pathology, which extends far beyond the basal ganglia to involve cortical, limbic, and peripheral autonomic structures [3, 4]