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The cell wall acts as a natural enteric capsule, shielding the GLP-1 molecules from pepsin and the acid bath of the stomach, and releasing it progressively as it transitions into the higher-pH environment of the duodenum

Further high-resolution 3D imaging to confirm endosomal GLP-1R localisation to ERMCSs included in situ correlative light and electron microscopy (CLEM) at room temperature to correlate ultrastructural features with positive fluorescent signals for SNAP/FLAG-hGLP-1R, EGFP-VAPB and mitochondria

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When administered, GLP-1 medications signal the brain to feel fuller faster and for longer periods, reduce cravings, and slow the rate at which food leaves the stomach