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Research on Combined Approaches A 2025 meta-analysis of 33 randomized controlled trials, involving 12,028 participants, revealed that adding lifestyle changes to GLP-1 therapy resulted in an additional 7.13 kg (15.7 lbs) of weight loss , a reduction in waist circumference by 5.74 cm , a drop in systolic blood pressure by 3.99 mmHg , and a decrease in fasting blood glucose by 6.51 mg/dL

Thirty-four participants receiving retatrutide (94.4 %) reported satisfaction with their weight loss during the clinical trial on a scale from 1 (least satisfied) to 10 (most satisfied)

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