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Fructose intake equivalent to 1520% of food energy increases plasma TG concentration by up to 3040% [124]

Specifically, circMETTL3-156aa, a novel peptide encoded by circMETTL3 derived from METTL3 in sHLH patient plasma exosomes, promotes M1 macrophage polarization by binding with LDHA and enhancing macrophage glycolysis