Food and Function, 3, 903915
They're not based on human models
MOTS-c treatment significantly (i) improves physical performance in young, middle-age, and old mice, (ii) regulates skeletal muscle metabolism and gene expression, and (iii) enhances adaptation to metabolic stress in C2C12 cells in an HSF1-dependent manner
Additionally, compared to conventional methods, supercritical fluid extraction protects bioactive compounds from air and light, reducing degradation and minimizing contamination risk from impure solvents (57)
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