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Sakarya, Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA

Common adverse effects include gastrointestinal symptoms, which affect the majority of patients to varying degrees: Nausea (20-44% of patients) usually most pronounced during dose escalation Diarrhea (20-30%) Constipation (15-24%) Vomiting (9-24%) Abdominal pain (6-10%) These symptoms typically diminish over time as physiological adaptation occurs

Ablative surgery with tumor-free margins remains the treatment of choice

Tng cng cho h min dch lun khe mnh ng thi phng nga cho c th khng b nhim c thuc hay kim loi

Eckel RH, Hanson AS, Chen AY, Berman JN, Yost TJ, Brass EP