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Symptoms of vitamin B12 deficiency can vary widely and may include fatigue, weakness, pale skin, shortness of breath, neurological symptoms such as numbness or tingling in the hands and feet, difficulty walking, memory loss, and mood changes

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TSP-1 floxed ( Thbs1 flox ) and full body TSP-1 deficient mice ( Thbs1 / ) were generated at the University of Pittsburgh Transgenic and Gene Targeting and Innovative Technologies Development Cores using CRISPR/Cas9 technology

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