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The results of these studies support and confirm observations in-vivo indicating that intact DSIP crosses the BBB by simple transmembrane diffusion
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It is important to take into consideration that many phytoconstituents have a low bioavailability when they are consumed orally as the body considered them xenobiotics (Kara et al., 2017) and, thus, may produce a significantly different result as that demonstrated from in vitro studies
Ethical Approval The manuscript is complying with the institutional ethical requirements
The results showed a significant increase in skin density and thickness, with a 67% reduction in wrinkle volume and improved elasticity, as measured by ultrasound and profilometry (Leyden et al., 2002)
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