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Even though it has been over a century since this devastating disease was discovered and despite massive research efforts over many long years, the specific cause of AD remains an enigma

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72 However, the expression of protein markers of astrocytes and neurons is unaffected by DVS, and the chronic unpredictable mild stress (CUMS)-induced reduction in the levels of myelin- and oligodendrocyte-related proteins can be prevented by DVS

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Transfection of specific siRNA targeting this receptor into MDMs blocked the reduction in LOX-1 expression induced by berberine