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References 47 and 48 provide proof that KINDLIN3 is mutated in LAD-III a disorder in which leukocyte integrins are expressed but do not function and show that wild-type KINDLIN3 cDNA reverses the LAD-III phenotype in lymphocytes

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Unlike diabetes, which is widely accepted as a chronic condition requiring ongoing pharmacologic management, obesity treatment often lacks the same framing, leading to premature discontinuation

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