Medications include compounded semaglutide and tirzepatide (503B pharmacy), brand-name Wegovy and Zepbound with PA support, and non-GLP-1 alternatives (topiramate, bupropion, metformin, orlistat) if you are ineligible
(Biochem Pharmacol 2018) documented a reduction of -35% in white adipose tissue, -40% in adipocyte volume, -5.1% in body weight and -30% in plasma cholesterol in just 11 days in obese mice (DIO), without any change in food intake
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Contraindications include a personal or family history of medullary thyroid carcinoma and multiple endocrine neoplasia syndrome type 2, with caution advised in those with a history of pancreatitis
Yes, certain medications promote weight gain and can counteract GLP-1 effects, including antipsychotics (olanzapine, clozapine), mood stabilizers (valproate, lithium), some antidepressants (mirtazapine, paroxetine), corticosteroids, and diabetes medications like insulin or sulfonylureas