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A specific weight-loss agent is generally continued when patients lose at least 5% of their initial body weight in the first three months without safety or tolerability concerns

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2 =3.40, df =2, P =0.18

53 Furthermore, elevated cholesterol levels in the microenvironment stimulate the expression of immune checkpoints, including PD-1, 2B4, TIM-3, and LAG-3, in T cells, driving T-cell exhaustion via the activation of the endoplasmic reticulum stress response

contributed to the study design